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README for GRCh38 annotation files
Last updated: July 1, 2020
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The files provided in this directory are symlinks to the latest 
assembly and annotation data available for the human GRCh38 assembly.

The latest version of the GRCh38 assembly is:
assembly name: GRCh38.p14
assembly accession: GCF_000001405.40
URL: https://www.ncbi.nlm.nih.gov/assembly/GCF_000001405.40/

The latest genome annotation available is:
assembly: GRCh38.p14
type: Updated annotation (current known RefSeqs + models)
name: Homo sapiens Annotation Release GCF_000001405.40-RS_2023_03
known RefSeqs from: 03-15-2023
model RefSeqs from: Annotation Release 110

files:
GRCh38_latest_genomic.fna.gz
GRCh38_latest_genomic.gff.gz
GRCh38_latest_genomic.gtf.gz
----------------------------
Files with genomic sequence in FASTA format and annotation in GFF3 or GTF format
for the latest annotated version of the GRCh38 assembly.

GRCh38_latest_protein.faa.gz
GRCh38_latest_protein.gpff.gz
GRCh38_latest_rna.fna.gz
GRCh38_latest_rna.gbff.gz
----------------------------
Files corresponding to the set of RefSeq RNA transcripts and proteins
annotated on the latest version of the GRCh38 assembly. Note some RefSeq
transcripts and proteins found in these files may not correspond to the
latest versions available in Entrez due to ongoing curation.

GRCh38_latest_knownrefseq_alignments.bam
GRCh38_latest_knownrefseq_alignments.bam.bai
GRCh38_latest_modelrefseq_alignments.bam
GRCh38_latest_modelrefseq_alignments.bam.bai
----------------------------
Files corresponding to alignments of known RefSeq transcripts (NM_* and
NR_* accession prefixes) and model RefSeq transcripts (XM_* and XR_* accession
prefixes) to the latest annotated version of the GRCh38 assembly.

Additional information about the genome annotation and alignment files 
is available at:
ftp://ftp.ncbi.nlm.nih.gov/genomes/Homo_sapiens/README


ClinVar annotation files are updated monthly:
FTP: ftp://ftp.ncbi.nlm.nih.gov/pub/clinvar/vcf_GRCh38/

The latest dbSNP annotation available is:
build: dbSNP human build 156 (b156)
release date: 11-04-2022
FTP: ftp://ftp.ncbi.nlm.nih.gov/snp/latest_release/VCF/

dbVar annotation files are updated periodically:
FTP: ftp://ftp.ncbi.nlm.nih.gov/pub/dbVar/data/Homo_sapiens/by_assembly/GRCh38/gvf/