Matched Annotation from NCBI and EMBL-EBI (MANE)

This track hub contains transcripts from the Matched Annotation from NCBI and EMBL-EBI (MANE) Project.

MANE is a collaboration between the National Center for Biotechnology Information (NCBI) and the European Molecular Biology Laboratories-European Bioinformatics Institute (EMBL-EBI). The goal of this project is to provide a minimal set of matching RefSeq and Ensembl transcripts of human protein-coding genes, where the transcripts from a matched pair are identical (5' UTR, coding region and 3' UTR), but retain their respective identifiers. The MANE transcript set is classified into three groups:

  1. MANE Select: One high-quality representative transcript per protein-coding gene that is well-supported by experimental data and represents the biology of the gene.
  2. MANE Plus: A minimal set of well-supported transcripts that have additional characteristics, such as significant novel exons, which are not included in the MANE Select transcript.
  3. MANE: All other matched transcripts that are not included in the Select and Plus sets.

Watch the MANE webinar on YouTube!

Track Display Conventions and Configuration

Releases up to version 0.9 contain a single track containing two identical transcripts for each gene, colored as follows:

  1. MANE Select transcript using NCBI identifiers
  2. MANE Select transcript using EMBL-EBI identifiers

Starting with version 0.91, two tracks are provided - one each with NCBI and EMBL-EBI identifiers.

  1. By default, only the transcript accession is shown in the label. This can be changed to combinations of transcript, protein and gene accessions.
  2. Transcripts within each track are colored as follows:
    1. MANE Select transcript
    2. MANE Plus Clinical transcript
  3. By default, both MANE Select and MANE Plus transcripts are displayed. But the tracks can be filtered to show only one type of transcripts.

Data Access

MANE data can be downloaded from the NCBI FTP site. Separate files are provided in GFF3, GTF, BigBed and FASTA formats for both the RefSeq and Ensembl identifiers, and additionally in GenBank flatfile format for the RefSeq transcripts and proteins.

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